BioCore SEC is a family of high performance, size exclusion chromatography columns designed for separating a broad range of biomolecules based on size. The column technology involves the creation of a neutral hydrophilic layer on the surface of specially designed, high-strength, monodispersed silica particles, combined with well-established column packing processes. BioCore SEC-300 columns are suited for aggregate and fragment determination in antibodies and related substances.